Immunoglobulin structures produced in response to non-self biological material and showing high binding affinity for the target
Specific molecular structure capable of eliciting an immune response leading to the production of antibodies
A system or method for interrogating a biological system
A biological parameter that serves to indicate a specific biological property; a biochemical feature or facet that can be used to measure the progress of disease or the effects of treatment.
Current Good Manufacturing Practice
European Medicines Evaluation Authority
Central Nervous System
Centre for Stem Cell Biology
Differentiation (cellular)
The progression of cell development from a more primitive state to a more mature, specialised state
The process of development leading to formation of the embryo
A cell population that serves to sustain another within a culture system
Good Laboratory Practice
The addition of carbohydrate groups to proteins or lipids
The process of isolating the inner cell mass of the embryo and obtaining a self-perpetuating populating of HESCs from it
Human Fertilization and Embryo Authority
Inner cell mass: a group of pluripotent cells found within the blastocyst stage of the early embryo
In the body (of a living organism)
In glass: in culture systems
Intellectual property
The gross chromosomal complement of a cell, including number, and any specific rearrangements of chromosome structure
Carbohydrate-binding protein molecules
A self perpetuating (dividing) population of cells, usually of the same type and often clonal
A pathway of differentiation leading to a restricted repertoire of cell types
The enzymatic addition of methyl (CH3) groups to cytosine nucleotides of DNA
Polymerase chain reaction: a method for exponentially amplifying regions of DNA using short DNA primer sequences that are extended by a thermostable DNA polymerase in a multiple phase reaction (in commercial terms is the term ‘PCR’ copyrighted?)
The observable characteristics of an organism or cell
Non-chromosomal DNA element capable of replication
Capable of differentiation along multiple lineages
A chemical or biological agent that promotes cell division
A region of DNA sequence to which RNA polymerase binds to initiate transcription for gene expression
Restoration of function of damaged organs, tissues or structures within the body by cell or cell targeting therapies
A system established to identify and measure the activity of specific signalling or other systems within a cell. Commonly this might include a genetic construct that includes a regulatory element that is responsive to the signalling system to be measured, driving expression of a gene the product of which can easily be assayed (e.g. green fluorescent protein)
Ribonucleic acid inhibition; degradation of specific single stranded messenger RNA within a cell induced by double-stranded RNA showing homology to the targeted sequence
Standard operating procedures; documented protocols pertaining to a specific process that are implemented to ensure uniformity
The transition of a cell from one lineage to another